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Patients with tuberculosis, peptic ulcer or diabetes mellitus should not be treated with any corticosteroid preparation without the advice of the physician. It should be borne in mind that the normal defensive responses of the oral tissues are depressed in patients receiving topical corticosteroid therapy. Virulent strains of oral microorganisms may multiply without producing the usual warning symptoms of oral infections. The small amount of steroid released when Kenalog in Orabase is used as recommended makes systemic effects very unlikely; however, these are a possibility when topical corticosteroid preparations are used over a long period of time.
If local irritation or sensitization should develop, Kenalog in Orabase should be discontinued and appropriate therapy instituted. If significant regeneration or repair of oral tissues has not occurred in 7 days, additional investigation into the oral lesion is advised.
